Four U.S. service members have now been killed in the escalating conflict with Iran, after one of the five troops previously listed as seriously wounded died from their injuries, according to U.S. Central Command (CENTCOM).

The latest death raises the toll from three to four, marking the first American combat fatalities since the launch of Operation Epic Fury, the joint U.S.–Israeli military campaign that began late last week. Officials said families of the fallen are being notified before the names are released publicly.

CENTCOM confirmed that five service members were initially reported as seriously wounded in the attack. One has since succumbed to injuries, while others remain hospitalized. Several additional troops sustained minor injuries, including concussions and shrapnel wounds, but are expected to return to duty.

The casualties come amid continued exchanges between U.S. forces and Iran, following coordinated strikes carried out by the United States and Israel against Iranian military and leadership targets. In response, Iran has launched ballistic missiles and drones at U.S. and allied positions across the region.

President Donald Trump said the operation will continue as long as necessary, while acknowledging the risk of further losses.