WASHINGTON D.C (VINnews) – Dr. Marty Makary, commissioner of the U.S. Food and Drug Administration since March 2025, is expected to resign Tuesday, according to multiple sources.

The departure comes after President Donald Trump approved a plan earlier this month to remove him amid ongoing internal conflicts at the agency, the sources said.

Makary, a Johns Hopkins University surgeon and vocal advocate for medical transparency, aligned himself with the “Make America Healthy Again” initiative. His confirmation by the Senate passed narrowly. During his roughly 14-month tenure, he faced criticism over the agency’s handling of vaping regulations, access to mifepristone, compounded versions of weight-loss drugs and broader management issues. His time in office included several unexpected drug rejections, significant staff turnover and policy clashes that rattled biotech markets.

The White House has not yet announced a successor. Makary’s exit could create short-term uncertainty in drug approvals, food safety oversight and medical device regulation.

Makary’s office and the FDA did not immediately respond to requests for comment.